INTRAVENOUS RATE OF ADMINISTRATION: The rate of infusion was 100 to 125 milliliters/hour of a 0.15 Normal hydrochloric acid solution in sterile water (Williams & Lyons, 1980g). Others prepared a 0.15 Normal hydrochloric acid solution by diluting 12.5 milliliters of concentrated hydrochloric acid (35% to 38%) to a total volume of 1 liter with sterile water (Williams & Lyons, 1980g). One group of clinicians prepared a 0.1 Normal hydrochloric acid solution by drawing 100 milliequivalents of concentrated hydrochloric acid into a syringe and filtering it through a disposable 0.22 micron filter as it was added to a liter of 5% dextrose in water or normal saline (Wagner et al, 1980g). Most studies recommend a 0.1 to 0.15 Normal hydrochloric acid solution prepared in sterile water, 5% dextrose in water or normal saline (Wagner et al, 1980g Williams & Lyons, 1980g). HYDROCHLORIC ACID (0.1N) is stable and compatible in VIAFLEX(R) PLASTIC CONTAINERS over a 24 hour storage period (Pers Comm, 1987). The ' Molarity' of a solution is the number of moles of solute in one liter of solution. The ' Normality' of a solution is the 'Molarity' multiplied by the number of equivalents per mole. Rate of H+ replacement =0.1 to 0.2 meq/kg per hour. The BE requires the measurement of blood pH, hemoglobin, and HCO3. May also be indicated if rapid correction of severe metabolic alkalosis is warranted (eg, cardiac arrhythmia or hepatic encephalopathy.)īase excess in blood (BE-B) is the number of mmol of strong acid that is needed to adjust to pH 7.4 a blood sample tested at pCO2 of 40 mm Hg and 37 C.It indicates the deviation in mmol/l of the buffer bases from the normal value.īE - B = (1 - 0.014)( - 24 + (1.43 + 7.7)(pH - 7.4)) IV HCl may be indicated in severe metabolic alkalosis (pH >7.55) or when NaCl or KCl cannot be administered because of volume overload or advanced renal failure. Indication: treatment of severe or refractory metabolic alkalosis. Therefore add 8.3 ml of 37% HCL to 1 liter of D5W or NS to create a 0.1N HCL solution.ġ2M (37% HCL) = 12 moles/L = 12 x 36.5 = 438 g/L = 438 mg/ml.

Rate of H+ replacement: 0.1 - 0.2 mEq/kg/hourįor example, 0.1 N solution IV at 100 mL/h provides about 10 mEq/h

H+ ion deficit (mEq) = 0.3 X weight (kg) X (measured HCO3 - desired HCO3 )

Sample filter: GE PTFE (Teflon®) Syringe Filters: Membrane compatible with most aggressive solutions. Solution should be filtered with a teflon 0.22 micron filter before adding to an IV bag. Serum electrolytes and blood gases should be measured every 4 hours. Concentrations >0.1 N have been reported to cause corrosive effects, even when administered through a central venous catheter. Solutions for infusion should NOT exceed 0.2 N (increased risk of hemolysis and increased venous irritation). Do NOT infuse via a peripheral vein! Injection of HCl into a peripheral vein may cause extravasation and can produce severe tissue necrosis. Hydrochloric acid solution should be administered through a central venous line to prevent vein irritation, thrombophlebitis, or tissue necrosis. This agent must be infused in glass or polyolefin container.

Hcl acid or base